Synthesis and biological studies of neutral technetium (V) complexes containing NNOS donor sets

Int J Rad Appl Instrum B. 1992 Jan;19(1):65-72. doi: 10.1016/0883-2897(92)90186-3.


Complexation of ligands containing an N3S donor set has been affected with [99mTc]. These are part of a ligand series of analogous structures which exhibit similar chemistry and potentially interesting biology. The complexes which have been characterized with [99Tc] as [TcOL] are neutral and lipophilic and their biological behaviour has been assessed in rats. After HPLC purification of the no-carrier added preparation, brain uptake of the tracers was greater than 1% at 15 min p.i. Muscle activity was significant with slow blood clearance.

MeSH terms

  • Animals
  • Blood Proteins / metabolism
  • Brain / diagnostic imaging*
  • Female
  • Ligands
  • Protein Binding
  • Radionuclide Imaging
  • Rats
  • Rats, Inbred Strains
  • Sodium Pertechnetate Tc 99m / chemistry
  • Sulfhydryl Compounds
  • Technetium*
  • Tissue Distribution


  • Blood Proteins
  • Ligands
  • Sulfhydryl Compounds
  • Technetium
  • Sodium Pertechnetate Tc 99m