Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand

Brain Res Mol Brain Res. 1992 Mar;13(1-2):175-8. doi: 10.1016/0169-328x(92)90060-o.


The development of the new ligand serotonin-5-O-carboxymethyl-glycyl [125I]tyrosinamide (abbreviated [125I]GTI) allows for the direct visualization of serotonin1B and serotonin1D (5-HT1B/1D) sites. Autoradiographic techniques were used to demonstrate the selective binding of this ligand to 5-HT1D sites in human post-mortem brain materials. The distribution of [125I]GTI binding sites was compared to [3H]5-HT sites in the presence of different displacers. The results show the selective binding of [125I]GTI to sites in the basal ganglia and substantia nigra which corresponds to 5-HT1D receptors.

MeSH terms

  • Aged
  • Autoradiography / methods
  • Basal Ganglia / metabolism
  • Binding, Competitive
  • Brain / metabolism*
  • Dipeptides / metabolism*
  • Guanylyl Imidodiphosphate / pharmacology
  • Humans
  • Iodine Radioisotopes
  • Kinetics
  • Mesencephalon / metabolism
  • Radioligand Assay
  • Receptors, Serotonin / analysis
  • Receptors, Serotonin / metabolism*
  • Serotonin / analogs & derivatives*
  • Serotonin / metabolism*


  • Dipeptides
  • Iodine Radioisotopes
  • Receptors, Serotonin
  • serotonin-O-carboxymethyl-Gly-Tyr
  • Serotonin
  • Guanylyl Imidodiphosphate