Assignment of the rat genes coding for alpha 1-antitrypsin (PI), phosphoenolpyruvate carboxykinase (PEPCK), alcohol dehydrogenase (ADH), and fructose-1,6-bisphosphatase (FDP)

Mamm Genome. 1992;3(1):42-5. doi: 10.1007/BF00355841.

Abstract

The chromosomal localization of four genes which are expressed mainly in the liver has been undertaken for the rat. Using a panel of hybrid clones segregating rat chromosomes, and Southern blot analysis, alpha 1-AT (PI), PEPCK, ADH and FDP are assigned to rat Chromosomes (Chr) 6, 3, 2 and 17, respectively. Groups of synteny among rat, mouse and human species are discussed in relationship to the new assignments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Dehydrogenase / genetics*
  • Animals
  • Chromosome Mapping*
  • Cloning, Molecular
  • Fructose-Bisphosphatase / genetics*
  • Hybrid Cells
  • Mice
  • Phosphoenolpyruvate Carboxykinase (GTP) / genetics*
  • Rats
  • alpha 1-Antitrypsin / genetics*

Substances

  • alpha 1-Antitrypsin
  • Alcohol Dehydrogenase
  • Fructose-Bisphosphatase
  • Phosphoenolpyruvate Carboxykinase (GTP)