The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site

J Virol. 1992 Jun;66(6):3946-9. doi: 10.1128/JVI.66.6.3946-3949.1992.

Abstract

The Bel-1 protein of human foamy virus can activate transcription directed by the long terminal repeat (LTR) promoter of human immunodeficiency virus type 1 (HIV-1). The target sequence for Bel-1 is shown to lie within the HIV-1 LTR U3 region but does not coincide with any previously described factor-binding site. Gene expression directed by an HIV-1 LTR lacking functional sites for the inducible cellular transcription factor NF-kappa B was activated over 100-fold by coexpression of Bel-1. These observations suggest that Bel-1 has the potential to significantly enhance the level of HIV-1 gene expression in cells dually infected with HIV-1 and human foamy virus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • DNA Mutational Analysis
  • DNA-Binding Proteins / genetics
  • Gene Expression Regulation, Viral / genetics*
  • HIV Long Terminal Repeat / genetics
  • HIV-1 / genetics
  • Molecular Sequence Data
  • NF-kappa B
  • Regulatory Sequences, Nucleic Acid / genetics*
  • Retroviridae / genetics*
  • Retroviridae Proteins / genetics
  • Spumavirus / genetics
  • Trans-Activators*
  • Transcription Factors / genetics*
  • Transcriptional Activation / genetics

Substances

  • DNA-Binding Proteins
  • NF-kappa B
  • Retroviridae Proteins
  • Trans-Activators
  • Transcription Factors
  • bel1 protein, Human foamy virus