Multiple genes for Xenopus activin receptor expressed during early embryogenesis

FEBS Lett. 1992 May 25;303(1):81-4. doi: 10.1016/0014-5793(92)80482-v.


Four distinct cDNAs for activin receptor designated as XSTK2, 3, 8 and 9 have been cloned from a Xenopus laevis cDNA library. The protein structures deduced from the cDNAs have shown that they all have a putative extracellular ligand-binding domain, a single transmembrane domain and cytoplasmic Ser/Thr kinase domain, except that XSTK2 is extremely similar to the XSTK3 gene but lacks a carboxyl-terminal part of the kinase motif. Northern blot analysis showed that all transcripts are maternally inherited. The levels of transcript for XSTK2, 3 and 8 appeared to fluctuate during early development while those for XSTK9 maintain constant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activin Receptors
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Blotting, Southern
  • DNA / genetics
  • Embryo, Nonmammalian / metabolism*
  • Molecular Sequence Data
  • Protein Kinases / genetics
  • RNA, Messenger / genetics
  • Receptors, Cell Surface / genetics*
  • Restriction Mapping
  • Sequence Alignment
  • Transcription, Genetic
  • Xenopus / embryology
  • Xenopus / metabolism*


  • RNA, Messenger
  • Receptors, Cell Surface
  • DNA
  • Protein Kinases
  • Activin Receptors