Signal transduction from cell surface to nucleus in development and disease

FASEB J. 1992 May;6(8):2581-90. doi: 10.1096/fasebj.6.8.1317309.

Abstract

Recent studies indicate that extracellular signals affect cell proliferation and differentiation by modulating transcription factor activity via protein phosphorylation cascades. This review discusses the basic outline of the eukaryotic signal transduction systems used to transmit information from the cell surface to the transcriptional machinery in the nucleus. Several examples that illustrate how these pathways control cell proliferation, differentiation and development are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Membrane / physiology*
  • Cell Nucleus / physiology*
  • Disease*
  • GTP-Binding Proteins / physiology
  • Growth / physiology*
  • Humans
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Oncogenes
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cell Surface / physiology
  • Signal Transduction*

Substances

  • Receptors, Cell Surface
  • Protein-Tyrosine Kinases
  • GTP-Binding Proteins