Idiopathic recurring stupor: a case with possible involvement of the gamma-aminobutyric acid (GABA)ergic system

Ann Neurol. 1992 May;31(5):503-6. doi: 10.1002/ana.410310507.


A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma-aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.

Publication types

  • Case Reports

MeSH terms

  • Benzodiazepines / blood
  • Benzodiazepines / cerebrospinal fluid
  • Coma / etiology
  • Coma / physiopathology
  • Electroencephalography
  • Flumazenil / therapeutic use
  • GABA-A Receptor Antagonists
  • Humans
  • Male
  • Middle Aged
  • Recurrence
  • Unconsciousness / drug therapy
  • Unconsciousness / etiology*
  • Unconsciousness / physiopathology
  • gamma-Aminobutyric Acid / physiology*


  • GABA-A Receptor Antagonists
  • Benzodiazepines
  • Flumazenil
  • gamma-Aminobutyric Acid