Cyclic Pentapeptide Endothelin Antagonists With High ETA Selectivity. Potency- And Solubility-Enhancing Modifications

J Med Chem. 1992 May 29;35(11):2139-42. doi: 10.1021/jm00089a028.

MeSH terms

  • Amino Acid Sequence
  • Cyclization
  • Endothelins / metabolism
  • Molecular Sequence Data
  • Peptides, Cyclic / chemical synthesis
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / pharmacology
  • Protein Conformation
  • Receptors, Cell Surface / antagonists & inhibitors*
  • Receptors, Cell Surface / metabolism
  • Receptors, Endothelin
  • Structure-Activity Relationship

Substances

  • Endothelins
  • Peptides, Cyclic
  • Receptors, Cell Surface
  • Receptors, Endothelin
  • cyclo(Trp-Asp-Pro-Val-Leu)