The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system

Clin Investig. 1992 Jan;70(1):28-37. doi: 10.1007/BF00422934.


The antibody specificity index (ASI) indicates the cerebrospinal fluid (CSF)/serum difference of antibody amounts per weight unit IgG (normal less than 1.5). It has proven to be the most sensitive inflammation parameter in CSF analysis so far, more sensitive than the Western blot, the "oligoclonal" response, and the empirical differentiation of CSF immunoglobulins. By this diagnostic criterion, several benign viral meningitis cases were found to be caused by the varicella/zoster virus. The diagnostic relevance of local zoster antibody synthesis was greatest in ganglionitis cases, e.g., in zoster oticus sine herpete (facial paresis) and acute radicular syndromes of the elderly. The diagnostic significance of the local immune response against measles, rubella, and zoster antigens (MRZ response) was ascertained further. Together with oligoclonal gamma-globulin fractionation, there is now only 1 out of 100 multiple sclerosis (MS) patients left who has been found to have a normal CSF.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Viral / cerebrospinal fluid*
  • Antibody Specificity / immunology*
  • Female
  • Herpes Simplex / diagnosis*
  • Herpes Simplex / immunology
  • Herpes Zoster / diagnosis*
  • Herpes Zoster / immunology
  • Herpesvirus 3, Human / immunology
  • Humans
  • Immunoglobulin G / cerebrospinal fluid*
  • Male
  • Measles virus / immunology
  • Middle Aged
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / immunology
  • Nervous System Diseases / diagnosis*
  • Nervous System Diseases / immunology
  • Neurologic Examination
  • Simplexvirus / immunology


  • Antibodies, Viral
  • Immunoglobulin G