Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices

Neurosci Lett. 1992 May 25;139(2):197-200. doi: 10.1016/0304-3940(92)90551-h.


Experiments were performed to investigate whether intact intracellular Ca2+ pools are necessary for long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Thapsigargin (1 microM), which depletes most intracellular Ca2+ pools by blocking ATP-dependent Ca2+ uptake into intracellular compartments, blocked the induction but not the expression of LTP. Thapsigargin had no effect on synaptic transmission or on responses mediated by N-methyl-D-aspartate (NMDA) receptor activation. These data suggest that Ca2+ release from intracellular stores is required for the induction of LTP.

MeSH terms

  • Animals
  • Calcium / physiology
  • Electric Stimulation
  • Evoked Potentials / drug effects
  • Female
  • Hippocampus / drug effects*
  • Hippocampus / physiology
  • In Vitro Techniques
  • Rats
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Synaptic Transmission / drug effects
  • Terpenes / pharmacology*
  • Thapsigargin


  • Receptors, N-Methyl-D-Aspartate
  • Terpenes
  • Thapsigargin
  • Calcium