Treatment with antioxidant and other nutrients in combination with chemotherapy and irradiation in patients with small-cell lung cancer

Anticancer Res. 1992 May-Jun;12(3):599-606.


Eighteen non-randomized patients with small cell lung cancer (4 women and 14 men, mean age 60.4, SD 7.8 years) received in addition to conservation small cell lung cancer treatment antioxidant treatment with vitamins, trace elements and fatty acids. All patients were out-patients who, except for one were also treated with chemotherapy and/or irradiation at regular intervals at a university of central hospital. Five patients (28%) were in an advanced stage of the disease. At the end of the follow-up period (31.7.90) the median survival time for the whole group was 505 days. Fourteen (77%) of the patients survived for more than 12 months and six patients (33%) for more than two years. One patient (5%) survived more than five years. Eight patients (44%) were still alive with a mean survival time of 32 months at the end of the study. Ten patients succumbed earlier from progression of the disease. Antioxidant treatment, in combination with chemotherapy and irradiation, prolonged the survival time of patients with small cell lung cancer compared to most published combination treatment regimens alone. We also noticed that the patients receiving antioxidants were able to tolerate chemotherapy and radiation treatment well. Surviving patients started antioxidant treatment in general earlier than those who succumbed.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Antioxidants / therapeutic use*
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / radiotherapy
  • Carcinoma, Small Cell / therapy*
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Fatty Acids, Essential / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / radiotherapy
  • Lung Neoplasms / therapy*
  • Male
  • Middle Aged
  • Trace Elements / blood
  • Trace Elements / therapeutic use*
  • Vincristine / administration & dosage
  • Vitamins / therapeutic use*


  • Antioxidants
  • Fatty Acids, Essential
  • Trace Elements
  • Vitamins
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide

Supplementary concepts

  • CAV protocol