Immunoreactivity for the beta chain of the platelet-derived growth factor receptor in malignant mesothelioma and non-neoplastic mesothelium

J Pathol. 1992 May;167(1):1-4. doi: 10.1002/path.1711670102.


The results of an immunohistochemical study of platelet-derived growth factor receptor (PDGF-R) beta chain in human non-neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using a murine monoclonal antibody are reported. In approximately half of the malignant mesotheliomas, there was immunoreactivity in the cytoplasm of the neoplastic cells for the beta chain of the PDGF-R. In some cases, there was also membrane immunoreactivity. There were no statistically significant differences between the various mesothelioma subtypes. Immunoreactivity for PDGF-R beta chain was absent in non-neoplastic mesothelium.

MeSH terms

  • Animals
  • Epithelium / chemistry*
  • Humans
  • Immunohistochemistry
  • Mesothelioma / chemistry*
  • Mesothelioma / pathology
  • Mice
  • Platelet-Derived Growth Factor / analysis*
  • Pleural Neoplasms / chemistry*
  • Pleural Neoplasms / pathology
  • Receptors, Cell Surface / analysis*
  • Receptors, Platelet-Derived Growth Factor


  • Platelet-Derived Growth Factor
  • Receptors, Cell Surface
  • Receptors, Platelet-Derived Growth Factor