Ga3+ inhibits parathyroid hormone release without interacting with the Ca2+ receptor of the parathyroid cell

Biochem Biophys Res Commun. 1992 Jul 15;186(1):556-61. doi: 10.1016/s0006-291x(05)80844-7.


Gallium nitrate is an antihypercalcemic agent with established actions on bone. The effects of Ga(NO3)3 on parathyroid hormone (PTH) release, cytoplasmic Ca2+ concentration ([Ca2+]i) and cAMP production of enzymatically dispersed parathyroid cells from bovine as well as normal and pathological human parathyroid glands have now been studied. Ga3+ at 200 microM inhibited PTH release whereas 600 microM NO3- had no effect. The inhibition was additive to that obtained by elevating extracellular Ca2+. Unlike Ca2+, Ga3+ failed to increase [Ca2+]i or reduce cAMP formation. The results indicate that Ga3+ inhibits PTH release by a mechanism other than activation of the cation receptor of the parathyroid cells. This mechanism may contribute also to inhibition by other cations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Calcium / metabolism*
  • Calcium / pharmacology
  • Calcium-Binding Proteins / drug effects
  • Calcium-Binding Proteins / metabolism*
  • Cattle
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism*
  • Cyclic AMP / metabolism
  • Fura-2
  • Gallium / pharmacology*
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Parathyroid Diseases / physiopathology
  • Parathyroid Glands / drug effects
  • Parathyroid Glands / metabolism*
  • Parathyroid Hormone / metabolism*
  • Parathyroid Neoplasms / physiopathology


  • Antineoplastic Agents
  • Calcium-Binding Proteins
  • Parathyroid Hormone
  • Gallium
  • Cyclic AMP
  • Calcium
  • Fura-2
  • gallium nitrate