Multiple histamine receptors: properties and functional characteristics

Biochem Soc Trans. 1992 Feb;20(1):122-5. doi: 10.1042/bst0200122.


Recent advances in molecular biological techniques have seen the cloning of the H2-receptor gene from canine parietal cells, and the structural identification and cloning of the H1- and H3-receptors should soon follow. This information will allow the elucidation of the mechanisms responsible for the species and tissue heterogeneity in the H1-receptor binding and functional characteristics. The mechanisms underlying the inhibitory effect of H3-receptor stimulation on neurotransmitter release remains to be established, but this receptor appears to be coupled to its effector system (perhaps an ion channel?) via a G-protein. Patch-clamp studies on histamine receptors in invertebrate neurones have identified a ligand-gated chloride channel at a photoreceptor synapse of the housefly and it remains an intriguing possibility that there is a counterpart in mammalian species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Histamine / analogs & derivatives
  • Histamine / metabolism
  • Histamine / pharmacology
  • Kinetics
  • Receptors, Histamine / drug effects
  • Receptors, Histamine / metabolism
  • Receptors, Histamine / physiology*
  • Receptors, Histamine H1 / metabolism
  • Receptors, Histamine H1 / physiology
  • Receptors, Histamine H2 / metabolism
  • Receptors, Histamine H2 / physiology
  • Receptors, Histamine H3
  • Signal Transduction


  • Receptors, Histamine
  • Receptors, Histamine H1
  • Receptors, Histamine H2
  • Receptors, Histamine H3
  • Histamine