Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

Curr Opin Genet Dev. 1992 Apr;2(2):275-85. doi: 10.1016/s0959-437x(05)80285-0.


It has been proposed that scaffold-associated regions are DNA elements that form the bases of chromatin loops in eukaryotic cells. Recent evidence supports a role for these elements as cis-acting 'handlers' of both structural and functional chromatin domains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Chromatin / chemistry*
  • Chromatin / physiology*
  • DNA Topoisomerases, Type II / physiology
  • DNA-Binding Proteins / physiology
  • Mitosis / physiology
  • Molecular Sequence Data


  • Chromatin
  • DNA-Binding Proteins
  • DNA Topoisomerases, Type II