Two TNF receptors

Immunol Today. 1992 May;13(5):151-3. doi: 10.1016/0167-5699(92)90116-O.


In the past few years, considerable progress has been made on the identification and characterization of tumor necrosis factor (TNF) receptors. The relative roles played by the two receptor types in signaling the diverse functions of TNF are less clear. Here, Louis Tartaglia and David Goeddel summarize progress to date and propose a model of TNF receptor triggering that reconciles the seemingly conflicting data.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Antibodies / immunology
  • Cell Line
  • Cloning, Molecular
  • Genes
  • Humans
  • Mice
  • Models, Biological
  • Molecular Weight
  • Receptor Aggregation
  • Receptors, Cell Surface / classification*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / immunology
  • Receptors, Cell Surface / isolation & purification
  • Receptors, Cell Surface / physiology
  • Receptors, Tumor Necrosis Factor
  • Sequence Homology, Nucleic Acid
  • Signal Transduction
  • Tumor Necrosis Factor-alpha*


  • Antibodies
  • Receptors, Cell Surface
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha