Ca2+ channels: diversity of form and function

Curr Opin Neurobiol. 1992 Jun;2(3):247-53. doi: 10.1016/0959-4388(92)90111-w.

Abstract

The past year has seen some significant advances in our understanding of the structural and functional properties of neuronal voltage-gated Ca2+ channels. Molecular cloning and protein purification studies have identified structural components, and expression studies are beginning to define the biophysical and pharmacological properties of the cloned channels. A number of studies of native Ca2+ channels show that the concept of channel modulation includes gating by both voltage and ligands.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium Channels / physiology*
  • Humans
  • Ion Channel Gating
  • Neurons / metabolism
  • Neurons / physiology

Substances

  • Calcium Channels