Nutrition and cancer

Clin Chem. 1992 Aug;38(8B Pt 2):1587-94.


Diet can play a key role in the pathogenesis of cancer. Diets high in fat and low in fiber predispose individuals to colon cancer. A high-fat diet is also implicated in breast cancer and prostate cancer. The dietary fat-cancer linkage is supported by epidemiological evidence, animal studies, and prospective trials. The antioxidants vitamin E, ascorbic acid, and beta-carotene have a protective effect and act as antipromoters of carcinogenesis. A diet of less than or equal to 10% of calories from fat and less than or equal to 40 g of fiber daily that includes fruits and vegetables will prevent up to 35% of cancers.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants
  • Diet
  • Dietary Fats
  • Dietary Fiber
  • Female
  • Humans
  • Male
  • Neoplasms* / epidemiology
  • Neoplasms* / etiology
  • Neoplasms* / prevention & control
  • Nutritional Physiological Phenomena*


  • Antioxidants
  • Dietary Fats
  • Dietary Fiber