Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27

Immunogenetics. 1992;36(5):302-5. doi: 10.1007/BF00215658.

Abstract

Genes encoding superantigens which delete Tcrb-V3+ T cells co-segregate with mouse mammary tumor proviruses (Mtv), Mtv-1, Mtv-3, Mtv-6, Mtv-13, and Mtv-44. We have examined percentages of Tcrb-V3+ T cells and Mtv integrations in [(B10 x NZB)F1 x B10.BR] mice, and show that Mtv-27 as well as Mtv-3 from NZB mice co-segregate with genes encoding deletion ligands for Tcrb-V3+ T cells without recombination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blotting, Southern
  • Genome, Viral
  • Lymphocyte Depletion
  • Mammary Tumor Virus, Mouse / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred NZB
  • Proviruses / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / analysis*
  • T-Lymphocytes / immunology*

Substances

  • Receptors, Antigen, T-Cell, alpha-beta