Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus

J Virol. 1992 Sep;66(9):5586-9.

Abstract

Here we describe an open reading frame (LMW23-NL) in the African swine fever virus genome that possesses striking similarity to a murine myeloid differentiation primary response gene (MyD116) and the neurovirulence-associated gene (ICP34.5) of herpes simplex virus. In all three proteins, a centrally located acidic region precedes a highly conserved, hydrophilic 56-amino-acid domain located at the carboxy terminus. LMW23-NL predicts a highly basic protein of 184 amino acids with an estimated molecular mass of 21.3 kDa. The similarity of LMW23-NL to genes involved in myeloid cell differentiation and viral host range suggests a role for it in African swine fever virus host range.

Publication types

  • Comparative Study

MeSH terms

  • African Swine Fever Virus / genetics*
  • African Swine Fever Virus / pathogenicity
  • Amino Acid Sequence
  • Animals
  • Antigens, Differentiation*
  • Base Sequence
  • Genes, Viral*
  • Genome, Viral
  • Macrophages / microbiology
  • Molecular Sequence Data
  • Proteins / genetics
  • Reading Frames
  • Sequence Homology, Nucleic Acid
  • Simplexvirus / genetics
  • Species Specificity
  • Swine
  • Viral Proteins / genetics*
  • Virulence

Substances

  • Antigens, Differentiation
  • Proteins
  • Viral Proteins
  • gamma 34.5 protein, Human herpesvirus 1
  • LMW23NL protein, African swine fever virus

Associated data

  • GENBANK/M95672