Mitogen-activated protein kinases: versatile transducers for cell signaling

Trends Biochem Sci. 1992 Jun;17(6):233-8. doi: 10.1016/s0968-0004(00)80005-5.


Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine protein kinases that are activated via phosphorylation of their own tyrosine residues. Highly conserved during eukaryotic evolution, they serve as common signaling components in distinct transduction pathways initiated by many stimuli. They have been implicated in the control of a broad spectrum of cellular events but are particularly known for their possible roles in cell cycle progression and the control of meiosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cell Communication / physiology*
  • Cell Cycle / physiology
  • Cyclins / physiology
  • Humans
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinases / physiology*
  • Signal Transduction / physiology*
  • Substrate Specificity


  • Cyclins
  • Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases