Cytogenetical observations in two cases of polymorphous low-grade adenocarcinoma of the salivary glands

Anticancer Res. Jul-Aug 1992;12(4):1195-8.

Abstract

The cytogenetical findings in two cases of cultured salivary polymorphous low-grade adenocarcinoma (PLGA) are reported. The first PLGA was a carcinoma ex pleomorphic adenoma of the parotid gland. This had a pseudodiploid stemline characterized by extensive and complicated structural rearrangements. The chromosomal findings showed many similarities to those in the only previously studied case of PLGA (also a carcinoma ex pleomorphic adenoma of the parotid). The results in both could fit with abnormalities superimposed on those typical of mixed tumors. The second PLGA reported derived from a minor salivary gland. It showed a completely different picture, distinguished by a hypodiploid, almost exclusively numerical, variation and the occurrence of a stemline characterized by only monosomy 22. Etiological differences were proposed as one possible explanation for the cytogenetical differences between the two types of PLGA.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Pleomorphic / genetics*
  • Adenoma, Pleomorphic / pathology
  • Adolescent
  • Aged
  • Female
  • Genetic Markers
  • Humans
  • Karyotyping
  • Male
  • Parotid Neoplasms / genetics*
  • Parotid Neoplasms / pathology
  • Salivary Gland Neoplasms / genetics*
  • Salivary Gland Neoplasms / pathology
  • Salivary Glands, Minor*

Substances

  • Genetic Markers