The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells

FEBS Lett. 1992 Sep 7;309(2):161-4. doi: 10.1016/0014-5793(92)81086-2.


We report here that angiotensin II (AII) and the AT2 receptor-selective ligand, CGP 42112, modulate the T-type calcium current in non-differentiated NG108-15 cells, which express only AT2 receptors. Both peptides decrease the T-type calcium current at membrane potentials above -40 mV and shift the current-voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT2 receptor mediates certain neurophysiological actions of this hormone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Angiotensin II / antagonists & inhibitors
  • Angiotensin II / physiology*
  • Angiotensin Receptor Antagonists
  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Cell Line
  • Neurons / physiology*
  • Receptors, Angiotensin / physiology*


  • Angiotensin Receptor Antagonists
  • Calcium Channels
  • Receptors, Angiotensin
  • Angiotensin II
  • Calcium