Design of a Functional Hexapeptide Antagonist of Endothelin

J Med Chem. 1992 Aug 21;35(17):3301-3. doi: 10.1021/jm00095a029.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Arachidonic Acid / metabolism
  • Endothelins / antagonists & inhibitors*
  • Endothelins / chemistry
  • Endothelins / pharmacology
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • Inositol Phosphates / metabolism
  • Molecular Sequence Data
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / physiology
  • Oligopeptides / chemistry
  • Oligopeptides / metabolism
  • Oligopeptides / pharmacology*
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology*
  • Rabbits
  • Rats
  • Receptors, Cell Surface / metabolism
  • Receptors, Endothelin
  • Structure-Activity Relationship
  • Vasoconstriction / drug effects

Substances

  • Endothelins
  • Inositol Phosphates
  • Oligopeptides
  • Peptide Fragments
  • Receptors, Cell Surface
  • Receptors, Endothelin
  • PD 142893
  • Arachidonic Acid