Effects of methylcobalamin on diabetic neuropathy

Clin Neurol Neurosurg. 1992;94(2):105-11. doi: 10.1016/0303-8467(92)90066-c.

Abstract

We studied the clinical and neurophysiological effects of methylcobalamin on patients with diabetic neuropathy. In a double-blind study, the active group showed statistical improvement in the somatic and autonomic symptoms with regression of signs of diabetic neuropathy. Motor and sensory nerve conduction studies showed no statistical improvement after 4 months. The drug was easily tolerated by the patients and no side effects were encountered.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Neuropathies / drug therapy*
  • Diabetic Neuropathies / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology
  • Neurologic Examination / drug effects
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / physiopathology
  • Reaction Time / drug effects
  • Reaction Time / physiology
  • Reflex, Stretch / drug effects
  • Reflex, Stretch / physiology
  • Sensation / drug effects
  • Sensation / physiology
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • Vitamin B 12 / analogs & derivatives*
  • Vitamin B 12 / therapeutic use

Substances

  • mecobalamin
  • Vitamin B 12