Cytogenetics of a case of eccrine spiradenoma

Hum Pathol. 1992 Sep;23(9):1085-7. doi: 10.1016/0046-8177(92)90274-7.


A cytogenetic study of an eccrine spiradenoma and two lymph node metastases, with a growth pattern and microscopic appearance typical for benign eccrine spiradenoma, revealed a 46,XY-5,del(16)(q22),+mar(t(?;5)(?::5q13----5qter)) karyotype. The finding of the same abnormal karyotype in the tumor and the metastases suggests a relationship between the chromosomal abnormalities and the clinical malignant behavior of this morphologic benign tumor.

Publication types

  • Case Reports

MeSH terms

  • Adenoma, Sweat Gland / genetics*
  • Adenoma, Sweat Gland / pathology
  • Aged
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Humans
  • Karyotyping*
  • Lymphatic Metastasis
  • Male
  • Metaphase
  • Thoracic Neoplasms / genetics*
  • Thoracic Neoplasms / pathology