Sequence of a second human KDEL receptor

J Mol Biol. 1992 Aug 20;226(4):913-6. doi: 10.1016/0022-2836(92)91039-r.


Retention of luminal endoplasmic reticulum (ER) proteins is mediated via a conserved carboxy-terminal tetrapeptide that serves as a signal for their retrieval from subsequent compartments of the secretory pathway. The signal is recognized by a receptor molecule that is believed to cycle between the Golgi apparatus and the ER. This receptor in Saccharomyces cerevisiae is encoded by the ERD2 gene, and a human cDNA homologue of the gene has been isolated. Binding of ligand by the product of this gene results in a shift of its steady-state location from Golgi to ER, suggesting that retrograde transport has been triggered. Here we report the identification of a related human protein with similar properties. This indicates that there are at least two distinct genes in humans that encode functional KDEL receptors.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biological Transport
  • Cells, Cultured
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Molecular Sequence Data
  • Multigene Family / genetics*
  • Protein Sorting Signals / metabolism
  • Receptors, Cell Surface / genetics*
  • Receptors, Peptide*
  • Sequence Homology, Nucleic Acid


  • KDEL receptor
  • Protein Sorting Signals
  • Receptors, Cell Surface
  • Receptors, Peptide

Associated data

  • GENBANK/X63745