Abstract
Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenal Cortex / metabolism
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Amino Acid Sequence
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Animals
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Blotting, Northern
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Cloning, Molecular
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Dose-Response Relationship, Drug
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GTP-Binding Proteins / metabolism
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Humans
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Melanocyte-Stimulating Hormones / physiology
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Melanocytes / metabolism
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Mice
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Molecular Sequence Data
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Polymerase Chain Reaction
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RNA, Messenger / biosynthesis
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Receptors, Corticotropin
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Receptors, Pituitary Hormone / biosynthesis
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Receptors, Pituitary Hormone / genetics*
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Sequence Homology, Nucleic Acid
Substances
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RNA, Messenger
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Receptors, Corticotropin
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Receptors, Pituitary Hormone
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MSH receptor
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Melanocyte-Stimulating Hormones
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GTP-Binding Proteins
Associated data
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GENBANK/X65633
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GENBANK/X65634
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GENBANK/X65635