Abstract
The effects of thrombin and a peptide mimicking the amino terminus of its receptor, Res (42-55), on vascular reactivity were compared in isolated canine blood vessels. In saphenous veins contracted with endothelin-1, both thrombin and Res (42-55) caused relaxation in rings with endothelium and contraction in rings without endothelium. In coronary arteries, thrombin caused similar responses while Res (42-55) only caused contraction. These data suggest that different thrombin receptors are present on venous and arterial endothelial cells.
MeSH terms
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Amino Acid Sequence
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Animals
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Coronary Vessels / drug effects
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Coronary Vessels / physiology
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Dogs
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Endothelins / pharmacology
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Endothelium, Vascular / drug effects*
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Endothelium, Vascular / physiology
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Molecular Sequence Data
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Muscle Contraction / drug effects*
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Peptide Fragments / pharmacology*
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Peptides / pharmacology*
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Receptors, Cell Surface / drug effects
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Receptors, Cell Surface / metabolism
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Receptors, Thrombin
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Saphenous Vein / drug effects
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Saphenous Vein / physiology
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Thrombin / pharmacology*
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Vasoconstriction / drug effects
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Vasodilation / drug effects
Substances
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Endothelins
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Peptide Fragments
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Peptides
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Receptors, Cell Surface
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Receptors, Thrombin
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thrombin receptor peptide (42-55)
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Thrombin