Venous and arterial endothelial cells respond differently to thrombin and its endogenous receptor agonist

Eur J Pharmacol. 1992 May 27;216(1):135-7. doi: 10.1016/0014-2999(92)90222-p.

Abstract

The effects of thrombin and a peptide mimicking the amino terminus of its receptor, Res (42-55), on vascular reactivity were compared in isolated canine blood vessels. In saphenous veins contracted with endothelin-1, both thrombin and Res (42-55) caused relaxation in rings with endothelium and contraction in rings without endothelium. In coronary arteries, thrombin caused similar responses while Res (42-55) only caused contraction. These data suggest that different thrombin receptors are present on venous and arterial endothelial cells.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Coronary Vessels / drug effects
  • Coronary Vessels / physiology
  • Dogs
  • Endothelins / pharmacology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / physiology
  • Molecular Sequence Data
  • Muscle Contraction / drug effects*
  • Peptide Fragments / pharmacology*
  • Peptides / pharmacology*
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / metabolism
  • Receptors, Thrombin
  • Saphenous Vein / drug effects
  • Saphenous Vein / physiology
  • Thrombin / pharmacology*
  • Vasoconstriction / drug effects
  • Vasodilation / drug effects

Substances

  • Endothelins
  • Peptide Fragments
  • Peptides
  • Receptors, Cell Surface
  • Receptors, Thrombin
  • thrombin receptor peptide (42-55)
  • Thrombin