3-Phenyl-4-hydroxyquinolin-2(1H)-ones: Potent and Selective Antagonists at the Strychnine-Insensitive Glycine Site on the N-methyl-D-aspartate Receptor Complex

J Med Chem. 1992 Sep 4;35(18):3423-5. doi: 10.1021/jm00096a019.

MeSH terms

  • Animals
  • Binding Sites
  • Glycine / antagonists & inhibitors*
  • Glycine / metabolism
  • Quinolones / pharmacology*
  • Rats
  • Receptors, N-Methyl-D-Aspartate / drug effects*
  • Structure-Activity Relationship
  • Strychnine / pharmacology*

Substances

  • Quinolones
  • Receptors, N-Methyl-D-Aspartate
  • Strychnine
  • Glycine