The indusium griseum in Alzheimer's disease: an immunocytochemical study

J Neurol Sci. 1992 Aug;111(1):39-45. doi: 10.1016/0022-510x(92)90110-7.


The immunocytochemical features of the indusium griseum (IG) were compared with the corresponding hippocampus in 5 patients with Alzheimer's disease (AD) and 5 age-matched nondemented individuals using antibodies against beta-amyloid, the A68 protein (Alz-50 antibody), tau, ubiquitin and synapsin I. beta-Amyloid-positive plaques were prominent in the AD hippocampus but were not present in the IG. Numerous Alz-50, tau and ubiquitin-positive neurofibrillary tangles and dystrophic neurites were observed in the AD hippocampus but were infrequent in the IG. Synapsin I immunoreactivity was significantly reduced in both the AD hippocampus and the AD IG when compared to age-matched patients. These findings suggest that the IG may be resistant to factors that trigger production of abnormal AD-associated proteins. Loss of synaptic input alone may not account for the AD-associated changes in the hippocampus since synaptic depletion was seen in both the hippocampus and the unaffected AD IG.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / immunology
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / biosynthesis
  • Antigens / biosynthesis
  • Female
  • Hippocampus / metabolism
  • Hippocampus / pathology*
  • Humans
  • Immunoglobulin G / immunology
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / biosynthesis
  • Synapsins / biosynthesis
  • Ubiquitins / biosynthesis
  • tau Proteins / biosynthesis


  • Alzheimer's disease antigen
  • Amyloid beta-Peptides
  • Antigens
  • Immunoglobulin G
  • Nerve Tissue Proteins
  • Synapsins
  • Ubiquitins
  • tau Proteins