doi: 10.1038/359609a0.
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
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- PMID: 1328888
- DOI: 10.1038/359609a0
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A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
Nature.
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Abstract
Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a relationship between activin and fibroblast growth factor.
Comment in
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Activins. No muscles, but what a brain.Nature. 1992 Oct 15;359(6396):586-7. doi: 10.1038/359586a0. Nature. 1992. PMID: 1406991 No abstract available.
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