Molecular diversity of glutamate receptors and implications for brain function

Science. 1992 Oct 23;258(5082):597-603. doi: 10.1126/science.1329206.


The glutamate receptors mediate excitatory neurotransmission in the brain and are important in memory acquisition, learning, and some neurodegenerative disorders. This receptor family is classified in three groups: the N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate, and metabotropic receptors. Recent molecular studies have shown that many receptor subtypes exist in all three groups of the receptors and exhibit heterogeneity in function and expression patterns. This article reviews the molecular and functional diversity of the glutamate receptors and discusses their implications for integrative brain function.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Brain / physiology*
  • Cloning, Molecular
  • Humans
  • Molecular Sequence Data
  • Oxadiazoles
  • Receptors, AMPA
  • Receptors, Glutamate* / chemistry
  • Receptors, Glutamate* / physiology
  • Receptors, Metabotropic Glutamate*
  • Receptors, N-Methyl-D-Aspartate* / chemistry
  • Receptors, N-Methyl-D-Aspartate* / physiology
  • Receptors, Neurotransmitter* / chemistry
  • Receptors, Neurotransmitter* / physiology


  • Oxadiazoles
  • Receptors, AMPA
  • Receptors, Glutamate
  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • metabotropic quisqualate receptor