Positron emission tomography for treatment evaluation and recurrence detection compared with CT in long-term follow-up cases of lung cancer

Clin Nucl Med. 1992 Nov;17(11):877-81. doi: 10.1097/00003072-199211000-00009.


Two cases of lung cancer were studied with positron emission tomography (PET) using L-[methyl-C-11]methionine (C-11 Met) and CT scans five to six times during long-term follow-up after radiotherapy. In a large cell carcinoma with mediastinal invasion, C-11 Met tumor uptake showed a rapid decrease after radiotherapy, corresponding to clinical improvement, and detected recurrence at 11 months, as confirmed by biopsy. Tumor volume by CT showed no significant changes during this time. A squamous cell carcinoma of the superior sulcus (Pancoast type) showed rapid changes in C-11 Met tumor uptake and similar changes in tumor volume during two courses of radiotherapy and recurrence over a period of 25 months. PET evaluation of tumor viability seems to be valuable for treatment evaluation, and results match the tumor volume changes measured by CT.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carbon Radioisotopes
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
  • Carcinoma, Non-Small-Cell Lung / epidemiology
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / epidemiology
  • Male
  • Methionine / analogs & derivatives
  • Middle Aged
  • Pancoast Syndrome / diagnostic imaging*
  • Pancoast Syndrome / epidemiology
  • Tomography, Emission-Computed*
  • Tomography, X-Ray Computed


  • Carbon Radioisotopes
  • Methionine
  • methionine methyl ester