New antiviral antibiotics, cycloviracins B1 and B2. I. Production, isolation, physico-chemical properties and biological activity

M Tsunakawa; N Komiyama; O Tenmyo; K Tomita; K Kawano; C Kotake; M Konishi; T Oki

doi:10.7164/antibiotics.45.1467

New antiviral antibiotics, cycloviracins B1 and B2. I. Production, isolation, physico-chemical properties and biological activity

J Antibiot (Tokyo). 1992 Sep;45(9):1467-71. doi: 10.7164/antibiotics.45.1467.

Authors

M Tsunakawa¹, N Komiyama, O Tenmyo, K Tomita, K Kawano, C Kotake, M Konishi, T Oki

Affiliation

¹ Bristol-Myers Squibb Research Institute, Tokyo, Japan.

PMID: 1331014
DOI: 10.7164/antibiotics.45.1467

Abstract

Kibdelosporangium albatum No. R761-7 (ATCC 55061) produced new antiviral antibiotics, cycloviracins B1 and B2. They show weak activity against Gram-positive bacteria and potent antiviral activity against herpes simplex virus type 1. Unique acylsaccharide structures were established for cycloviracins B1 and B2 by degradation and spectroscopic analysis.

MeSH terms

Actinomycetales / chemistry*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Antiviral Agents / chemistry
Antiviral Agents / isolation & purification*
Antiviral Agents / pharmacology
Macrolides*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Simplexvirus / drug effects

Substances

Anti-Bacterial Agents
Antiviral Agents
Macrolides
cycloviracin B1
cycloviracin B2