Effect of folate on cervical cancer. Synergism among risk factors

Ann N Y Acad Sci. 1992 Sep 30;669:293-9. doi: 10.1111/j.1749-6632.1992.tb17108.x.


Folate deficiency appears to play a crucial role early in cervical carcinogenesis by facilitating the incorporation of HPV genomes at a fragile chromosomal site. Thereafter, multiple nutritional, hormonal, and immunologic factors probably interact in a synergistic manner to determine whether the cell line becomes immortalized and invasive.

Publication types

  • Review

MeSH terms

  • Female
  • Folic Acid / metabolism*
  • Folic Acid Deficiency / physiopathology*
  • Genes, Tumor Suppressor
  • Humans
  • Oncogenes
  • Papillomaviridae / genetics
  • Risk Factors
  • Uterine Cervical Dysplasia / microbiology
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / etiology*
  • Uterine Cervical Neoplasms / genetics
  • Uterine Cervical Neoplasms / microbiology


  • Folic Acid