A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice

Anticancer Res. Sep-Oct 1992;12(5):1403-6.


A new nude-mouse metastasizing orthotopic transplant model of human small-cell carcinoma of the lung is described. Histologically-intact human small-cell lung tumors were transplanted to the left lung of nude mice via a thoracotomy procedure we have developed. The transplanted tumors grew extensively locally and metastasized to the opposite lung, lymph nodes and other clinically-relevant sites. The results described indicate the model developed could have clinical relevance and contrasts with models of small-cell carcinoma constructed with injections of cell suspensions which result in few or no metastases.

MeSH terms

  • Animals
  • Carcinoma, Small Cell / pathology*
  • Carcinoma, Small Cell / secondary*
  • Cell Division
  • Disease Models, Animal
  • Female
  • Humans
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / secondary*
  • Male
  • Mice
  • Mice, Nude
  • Neoplasm Metastasis / pathology*
  • Neoplasm Transplantation / methods
  • Thoracotomy
  • Transplantation, Heterologous