Abstract
CPT-11 and Topotecan are a new semisynthetic derivative of CPT, and have been shown to inhibit DNA topoisomerase I and to have a strong antitumor activity with low toxicity against murine tumor. On the other hard, the new antitumor compounds, NC-190 and IST-622 have been shown to inhibit DNA topoisomerase II, and the clinical study are currently under progress. A phase II study of CPT-11 demonstrated that CPT-11 was a very active agent which a acceptable toxicities against patient with advanced non-small cell lung cancer and small cell lung cancer.
MeSH terms
-
Animals
-
Antineoplastic Agents / administration & dosage
-
Antineoplastic Agents / therapeutic use*
-
Camptothecin / administration & dosage
-
Camptothecin / analogs & derivatives*
-
Camptothecin / therapeutic use
-
Carcinoma, Non-Small-Cell Lung / drug therapy
-
Carcinoma, Small Cell / drug therapy
-
Drug Administration Schedule
-
Female
-
Humans
-
Irinotecan
-
Lung Neoplasms / drug therapy*
-
Male
-
Mice
-
Phenazines / therapeutic use
-
Topoisomerase I Inhibitors*
-
Topotecan
Substances
-
Antineoplastic Agents
-
Phenazines
-
Topoisomerase I Inhibitors
-
NC 190
-
Irinotecan
-
Topotecan
-
Camptothecin