Active oxygen species, articular inflammation and cartilage damage

EXS. 1992;62:308-22. doi: 10.1007/978-3-0348-7460-1_31.

Abstract

Rheumatoid arthritis and osteoarthritis are age-related diseases, in which degenerative changes (arthrosis) and superimposed inflammatory reactions (arthritis) lead to progressive destruction of the joints. Active oxygen species derived from various sources play a role in this process, which may be influenced by appropriate treatment with antioxidants and free radical scavengers.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Antioxidants / therapeutic use*
  • Arthritis / drug therapy
  • Arthritis / physiopathology*
  • Cartilage, Articular / growth & development
  • Cartilage, Articular / physiopathology
  • DNA Damage
  • Free Radicals / metabolism
  • Humans
  • Hydroxides / metabolism
  • Hydroxyl Radical
  • Inflammation
  • Joints / growth & development
  • Joints / physiopathology
  • Lipid Peroxidation
  • Xanthine Oxidase / metabolism

Substances

  • Antioxidants
  • Free Radicals
  • Hydroxides
  • Hydroxyl Radical
  • Xanthine Oxidase