Isolation and characterization of an antiviral flavonoid from Waldsteinia fragarioides

M Abou-Karam; W T Shier

doi:10.1021/np50088a022

Isolation and characterization of an antiviral flavonoid from Waldsteinia fragarioides

J Nat Prod. 1992 Oct;55(10):1525-7. doi: 10.1021/np50088a022.

Authors

M Abou-Karam¹, W T Shier

Affiliation

¹ Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.

PMID: 1333516
DOI: 10.1021/np50088a022

Abstract

The antiviral agent in a fraction from Waldsteinia fragarioides (Rosaceae) was purified using bioassay-guided fractionation of activity against herpes simplex type 1 virus. Structural eluciation by instrumental methods identified the active component to be the known flavonoid glycoside, isoquercitrin (3,3',4',5,7-pentahydroxyflavone-3 beta-O-glucoside), which had not previously been shown to possess antiviral activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / isolation & purification*
Antiviral Agents / pharmacology
Flavonoids / isolation & purification*
Flavonoids / pharmacology
HIV-1 / drug effects
Magnetic Resonance Spectroscopy
Plant Extracts / chemistry
Plant Extracts / isolation & purification*
Plant Extracts / pharmacology
Plants, Medicinal / chemistry*
Simplexvirus / drug effects
Viral Plaque Assay

Substances

Antiviral Agents
Flavonoids
Plant Extracts