Sensitivity of in vivo MRS of the N-delta proton in proximal histidine of deoxymyoglobin

Magn Reson Med. 1992 Oct;27(2):362-7. doi: 10.1002/mrm.1910270217.

Abstract

The sensitivity of in vivo MRS of the N-delta proton of the proximal histidine of deoxymyoglobin in human skeletal muscles is discussed. Longitudinal relaxation time T1 of this deoxymyoglobin signal was measured in cuffed human forearms at 1.5 T and found to be 9.9 ms. Deoxymyoglobin spectra can be obtained from a forearm in seconds. The detection sensitivity of deoxymyoglobin in fully ischemic skeletal muscles and that of 31P MRS of PCr in normal resting muscles are compared.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Cattle
  • Female
  • Forearm / blood supply
  • Histidine / metabolism*
  • Humans
  • Ischemia / metabolism
  • Magnetic Resonance Spectroscopy* / methods
  • Male
  • Muscles / blood supply
  • Muscles / metabolism*
  • Myocardium / metabolism
  • Myoglobin / analogs & derivatives*
  • Myoglobin / metabolism
  • Phosphocreatine / metabolism
  • Phosphorus
  • Protons

Substances

  • Myoglobin
  • Protons
  • deoxymyoglobin
  • Phosphocreatine
  • Phosphorus
  • Histidine