p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo

Oncogene. 1992 Dec;7(12):2439-45.

Abstract

A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding murine p120. The encoded protein lacks significant homology with any reported protein, but it contains four copies of an imperfect 42 amino acid repeat that occurs 12.5 times in the protein encoded by Drosophila armadillo (arm), and its direct homologs, human plakoglobin (plak) and Xenopus laevis beta-catenin (beta-cat). The presence of this motif implies that p120 may share at least one aspect of its function with the arm protein and its homologs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Armadillo Domain Proteins
  • Base Sequence
  • Cadherins / genetics*
  • Cell Adhesion Molecules / genetics*
  • Cloning, Molecular
  • Cytoskeletal Proteins / genetics*
  • DNA / genetics*
  • DNA / isolation & purification
  • DNA Probes
  • Desmoplakins
  • Drosophila / genetics
  • Drosophila Proteins*
  • Gene Library
  • Humans
  • Insect Hormones / genetics
  • Mice
  • Molecular Sequence Data
  • Oncogene Protein pp60(v-src) / metabolism*
  • Phosphoproteins / genetics*
  • Phosphoproteins / isolation & purification
  • Phosphoproteins / metabolism*
  • Polymerase Chain Reaction / methods
  • Protein-Tyrosine Kinases / metabolism*
  • Proteins / genetics*
  • Receptors, Cell Surface / metabolism*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Substrate Specificity
  • Trans-Activators*
  • Transcription Factors
  • Xenopus
  • Xenopus Proteins
  • beta Catenin
  • gamma Catenin

Substances

  • ARM protein, Drosophila
  • Armadillo Domain Proteins
  • CTNNB1 protein, Xenopus
  • CTNNB1 protein, human
  • CTNNB1 protein, mouse
  • Cadherins
  • Cell Adhesion Molecules
  • Cytoskeletal Proteins
  • DNA Probes
  • Desmoplakins
  • Drosophila Proteins
  • Insect Hormones
  • Phosphoproteins
  • Proteins
  • Receptors, Cell Surface
  • Trans-Activators
  • Transcription Factors
  • Xenopus Proteins
  • beta Catenin
  • gamma Catenin
  • DNA
  • Protein-Tyrosine Kinases
  • Oncogene Protein pp60(v-src)