Physical mapping of human loci homologous to the chicken nov proto-oncogene

Oncogene. 1992 Dec;7(12):2529-34.

Abstract

The human locus (novH) corresponding to the nov protooncogene overexpressed in avian nephroblastoma has been identified and mapped on chromosome 8q24.1. Another locus sharing homology with novH and corresponding to the connective tissue growth factor (CTGF) gene has also been mapped on chromosome 6q23.1. The chromosomal assignment of nov and CTGF proximal to c-myc and c-myb respectively is of interest because chromosomal abnormalities involving these regions have been associated with different human tumors including Wilms'.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chickens
  • Chromosome Banding
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 8*
  • Connective Tissue Growth Factor
  • Cricetinae
  • Genes, myc
  • Growth Substances / genetics
  • Humans
  • Hybrid Cells
  • Immediate-Early Proteins*
  • Intercellular Signaling Peptides and Proteins*
  • Karyotyping
  • Kidney Neoplasms / genetics*
  • Nephroblastoma Overexpressed Protein
  • Oncogenes
  • Proto-Oncogenes*
  • Restriction Mapping
  • Wilms Tumor / genetics*

Substances

  • CCN2 protein, human
  • CCN3 protein, human
  • Growth Substances
  • Immediate-Early Proteins
  • Intercellular Signaling Peptides and Proteins
  • Nephroblastoma Overexpressed Protein
  • Connective Tissue Growth Factor