Fatal disseminated Conidiobolus coronatus infection in a renal transplant patient

Am J Clin Pathol. 1992 Dec;98(6):559-64. doi: 10.1093/ajcp/98.6.559.


A case of fatal disseminated fungal infection due to Conidiobolus coronatus in a patient with a renal transplant is described. This organism, known to cause localized infections in otherwise healthy individuals in the tropics, is now recognized as a cause of fatal infection in immunosuppressed hosts. Histologically, localized infections are characterized by lack of vessel invasion and the presence of an eosinophilic sleeve around fungal elements, called the Splendore-Hoeppli phenomenon. The histologic findings in the present case were more typical of mucormycosis, and the correct diagnosis was established only after the organism was isolated and identified in culture.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Cytomegalovirus Infections / etiology
  • Histoplasmosis / etiology
  • Humans
  • Kidney Transplantation*
  • Lung / microbiology
  • Lung / pathology
  • Male
  • Microbiological Techniques
  • Middle Aged
  • Mycoses / etiology*
  • Mycoses / microbiology
  • Mycoses / mortality
  • Postoperative Complications
  • Radiography, Thoracic