[The central thermoregulatory action of cholecystokinin-8 and prostaglandin E1]

Fiziol Zh SSSR Im I M Sechenova. 1992 Apr;78(4):94-101.
[Article in Russian]


In unanesthetized rats, the effects of intracerebroventricular injections of prostaglandin E1 (PGE1) and cholecystokinin octapeptide (CCK-8) on body temperature (Tb) regulation were studied. Both PGE1 and CCK-8 evoke hyperthermic responses of short latency and duration. Each substance raises the temperature, irrespective of initial temperature (Tbi). However, the maximal change in Tb and the rate of Tb rise depends on Tbi. A similarity of PGE1 and CCK-8 central thermoregulatory effects and putative roles of these substances in the mechanisms of fever, are discussed.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Alprostadil / administration & dosage
  • Alprostadil / pharmacology*
  • Animals
  • Body Temperature / drug effects
  • Body Temperature / physiology
  • Body Temperature Regulation / drug effects*
  • Body Temperature Regulation / physiology
  • Colon
  • Fever / chemically induced
  • Injections, Intraventricular
  • Male
  • Rats
  • Rats, Wistar
  • Sincalide / administration & dosage
  • Sincalide / pharmacology*
  • Skin Temperature / drug effects
  • Skin Temperature / physiology


  • Alprostadil
  • Sincalide