Intragenic suppression: Stalker, a retrovirus-like transposable element, can compensate for a deficiency at the cut locus of Drosophila melanogaster

Genetica. 1992;86(1-3):305-11. doi: 10.1007/BF00133729.


A number of mutations at the cut locus were induced by non-precise excision of a silent P-element insertion which resulted in deletions at the regulatory region of the locus. Unexpectedly, a reversion of one of these mutations was found, which appears as a result of insertion of Stalker (a retrovirus-like mobile element) near the 1.3 kb deletion. Thus an insertion of a retrovirus-like mobile element can suppress the deficiency at the regulatory region of a gene.

MeSH terms

  • Animals
  • Crosses, Genetic
  • DNA Mutational Analysis
  • DNA Transposable Elements* / genetics
  • Defective Viruses / genetics*
  • Drosophila Proteins
  • Drosophila melanogaster / genetics*
  • Female
  • Homeodomain Proteins
  • In Situ Hybridization
  • Male
  • Mutagenesis, Insertional
  • Nerve Tissue Proteins / deficiency
  • Nerve Tissue Proteins / genetics*
  • Nuclear Proteins / deficiency
  • Nuclear Proteins / genetics*
  • Regulatory Sequences, Nucleic Acid
  • Retroviridae / genetics*
  • Suppression, Genetic*
  • Transcription Factors


  • DNA Transposable Elements
  • Drosophila Proteins
  • Homeodomain Proteins
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Transcription Factors
  • ct protein, Drosophila