Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

Int J Rad Appl Instrum A. 1992 Dec;43(12):1443-7. doi: 10.1016/0883-2889(92)90170-j.


Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

MeSH terms

  • Antibodies*
  • Chelating Agents*
  • Deferoxamine*
  • Evaluation Studies as Topic
  • Isotope Labeling / methods*
  • Radioisotopes*
  • Zirconium*


  • Antibodies
  • Chelating Agents
  • Radioisotopes
  • Zirconium
  • Deferoxamine