Why is the genome variable? Insights from Drosophila

Trends Genet. 1992 Oct;8(10):355-62. doi: 10.1016/0168-9525(92)90281-8.


The analysis of variation in DNA restriction maps and DNA sequence in natural populations of Drosophila melanogaster and related species has revealed a remarkable richness of diversity. This review describes some of the results of population genetic studies of this variation that are beginning to reveal how interactions between natural selection, genetic drift, mutation rate, recombination rate and population size have contributed to the observed patterns.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • DNA Transposable Elements
  • Drosophila / genetics*
  • Genetic Variation*
  • Genetics, Population
  • Polymorphism, Genetic


  • DNA Transposable Elements