Encephalomyocarditis (EMC) virus-induced myocarditis by different virus variants and mouse strains

J Vet Med Sci. 1992 Dec;54(6):1125-9. doi: 10.1292/jvms.54.1125.


The mode of occurrence of encephalomyocarditis (EMC) virus-induced myocarditis in mice was pathologically and virologically investigated using 2 virus variants (highly diabetogenic EMC-D and non-diabetogenic EMC-B) and 2 mouse strains (diabetes-susceptible BALB/c and diabetes-resistant C57BL/6). Mice were inoculated with 10(5) PFU/head of the virus intraperitoneally and observed up to 7 days post inoculation (7DPI). As compared with EMC-B-infected BALB/c and EMC-D-infected C57BL/6 mice, EMC-D-infected BALB/c mice developed marked myocarditis and exhibited a heart virus titer of more than 100 times above that of the others after 4DPI. Electron microscopically, small aggregations of virus-like particles, with 20-25 nm in diameter, were found in the cytoplasm of degenerated cardiomyocytes showing mitochondrial and myofibrillar degeneration in EMC-D-infected BALB/c mice.

MeSH terms

  • Animals
  • Encephalomyocarditis virus*
  • Enterovirus Infections / blood
  • Enterovirus Infections / pathology
  • Enterovirus Infections / veterinary*
  • Hyperglycemia / microbiology
  • Hyperglycemia / veterinary
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Microscopy, Electron / veterinary
  • Myocarditis / microbiology
  • Myocarditis / pathology
  • Myocarditis / veterinary*
  • Rodent Diseases / blood
  • Rodent Diseases / microbiology*
  • Rodent Diseases / pathology
  • Species Specificity