Transcriptional regulation and transpositional selection of active SINE sequences

Curr Opin Genet Dev. 1992 Dec;2(6):874-82. doi: 10.1016/s0959-437x(05)80110-8.

Abstract

Alu repeats are short interspersed elements whose transposition has lead to genetic variability and heritable disorders in humans. A select subset of the nearly one million Alu sequences in human DNA actually produce new transpositions. The evolution of newly inserted Alu repeats is currently a key subject for study. Mechanisms of RNA polymerase III activity and the sequence environment into which an Alu inserts might select for transcriptional and posttranscriptional determinants of Alu transposition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Biological Evolution
  • DNA Transposable Elements*
  • Gene Expression Regulation
  • Humans
  • Molecular Sequence Data
  • Repetitive Sequences, Nucleic Acid*
  • Transcription, Genetic*

Substances

  • DNA Transposable Elements